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MOLECULAR AND CELLULAR BIOLOGY, July 2005, p. 54175428 Vol. 25, No. 13 0270-7306/05/$08.00 0 doi:10.1128/MCB.25.13.54175428.2005

Summary: MOLECULAR AND CELLULAR BIOLOGY, July 2005, p. 5417­5428 Vol. 25, No. 13
0270-7306/05/$08.00 0 doi:10.1128/MCB.25.13.5417­5428.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Differential Regulation of Estrogen-Inducible Proteolysis and
Transcription by the Estrogen Receptor N Terminus
Christopher C. Valley,1
Raphaešl MeŽtivier,2
Natalia M. Solodin,1
Amy M. Fowler,1
Mara T. Mashek,1
Lindsay Hill,1
and Elaine T. Alarid1
Department of Physiology, University of Wisconsin--Madison, Madison, Wisconsin 53706,1
and Equipe
d'Endocrinologie MoleŽculaire de la Reproduction (EMR), Universite de Rennes I,
35042 Rennes Cedex, France2
Received 15 November 2004/Returned for modification 14 February 2005/Accepted 31 March 2005
The ubiquitin-proteasome pathway has emerged as an important regulatory mechanism governing the
activity of several transcription factors. While estrogen receptor (ER ) is also subjected to rapid ubiquitin-


Source: Alarid, Elaine T. - Molecular and Cellular Pharmacology Training Program & Department of Oncology,University of Wisconsin at Madison


Collections: Biology and Medicine