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A model of dopamine modulated cortical activation F. Gregory Ashby*, Michael B. Casale
 

Summary: A model of dopamine modulated cortical activation
F. Gregory Ashby*, Michael B. Casale
Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA 93106, USA
Received 26 August 2002; revised 22 January 2003; accepted 22 January 2003
Abstract
Standard techniques from pharmacology and current theories on the biochemistry of dopamine (DA) are used to derive a new model of
how DA modulates cortical activation. The model assumes that DA potentiates the glutamate response through the NMDA receptor and
depresses the glutamate response through non-NMDA receptors. A static version of the model is used to examine the neurobiological
plausibility of the Servan-Schreiber, Printz, and Cohen model [Science 249 (1990) 892]. A dynamic version can be used to model many
behaviors that are outside the domain of the static [Science 249 (1990) 892] model, including single-cell recording data. As a preliminary test
of the model, we show that it can account for some single-cell recording data that examined the effects of DA on the firing rate of
glutamatergic cortical cells.
q 2003 Elsevier Science Ltd. All rights reserved.
Keywords: Dopamine; Glutamate; Prefrontal cortex; Computational modeling; Occupation theory
1. A model of dopamine modulated cortical activation
Dopamine (DA) has been assumed to modulate perform-
ance in a great many cognitive tasks, and DA imbalances
have been implicated in a variety of different neurological
disorders. As a result, DA plays a significant role in many
recent computational theories of cortical function (Ashby,

  

Source: Ashby, F. Gregory - Department of Psychology, University of California at Santa Barbara

 

Collections: Biology and Medicine; Computer Technologies and Information Sciences