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Leading Edge Cell 132, January 11, 2008 2008 Elsevier Inc. 19

Summary: Leading Edge
Cell 132, January 11, 2008 2008 Elsevier Inc. 19
Cell growth and differentiation require
dramatic rearrangements of the microtu-
bule cytoskeleton. Microtubules are pri-
marily remodeled by addition and loss of
tubulin subunits at their ends, so it is no
surprise that cells contain many micro-
tubule-associated proteins that bind to
and regulate microtubule tips (for exam-
ple, see Akhmanova and Hoogenraad,
2005). Several large conserved families
of tip-binding proteins have been iden-
tified, all of which are implicated in cell
morphogenesis in a variety of contexts.
However progress toward understand-
ing how tip-binding proteins alter micro-
tubule dynamics has been comparatively
slow, partly due to a lack of techniques


Source: Asbury, Chip - Department of Physiology and Biophysics, University of Washington at Seattle


Collections: Biology and Medicine