| | |
Summary: Structural RNAs of known and unknown function
identified in malaria parasites by comparative
genomics and RNA analysis
KAUSIK CHAKRABARTI,1,2
MICHAEL PEARSON,1
LESLIE GRATE,1
TIMOTHY STERNE-WEILER,2
JONATHAN DEANS,2
JOHN PAUL DONOHUE,1
and MANUEL ARES, JR.1,2
1
Department of Molecular, Cell and Developmental Biology, Center for Molecular Biology of RNA, University of California Santa Cruz,
Santa Cruz, California 95064, USA
2
Hughes Undergraduate Research Laboratory, University of California Santa Cruz, Santa Cruz, California 95064, USA
ABSTRACT
As the genomes of more eukaryotic pathogens are sequenced, understanding how molecular differences between parasite and
host might be exploited to provide new therapies has become a major focus. Central to cell function are RNA-containing
complexes involved in gene expression, such as the ribosome, the spliceosome, snoRNAs, RNase P, and telomerase, among
others. In this article we identify by comparative genomics and validate by RNA analysis numerous previously unknown
|
