Summary: university of california, santa barbara
P a g e 8 | W . M . K e c K F o u n d a t i o n
The Foundation will continue to fund development of pioneering
instrumentation, providing us with"new eyes" to detect what
has not been previously detected.
Structural changes of proteins are of enormous
importance in all biological processes.
unfortunately, our ability to measure these
subtle changes is limited by many factors, including the
complication that most proteins perform their acrobatics in
aqueous solution. Water absorbs many wavelengths and at
terahertz frequencies is almost "black" to sensors. nonetheless,
researchers led by Mark Sherwin, a physicist at the institute for
terahertz Science and technology at ucSB, are developing
the complementary techniques of terahertz absorption
spectroscopy and ultra-fast pulsed electron paramagnetic
resonance spectroscopy to establish the technology needed to
"film" the dynamics of biomolecules in solution.
at wavelengths of 30 micrometers to 1 millimeter, terahertz
radiation is between microwave and infrared. the dynamics