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COGNITIVE NEUROSCIENCE Cholinergic control of cortical network interactions enables

Cholinergic control of cortical network interactions enables
feedback-mediated attentional modulation
Gustavo Deco1
and Alexander Thiele2
Department of Technology, Computational Neuroscience, Institucio´ Catalana de Recerca i Estudis Avanc¸ats (ICREA), Universitat
Pompeu Fabra, Roc Boronat, 138, 08018 Barcelona, Spain
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
Keywords: acetylcholine, attention, attractor networks, feedback, visual cortex
Attention increases our ability to detect behaviorally relevant stimuli. At the neuronal level this is supported by increased firing rates of
neurons representing the attended object. In primary visual cortex an attention-mediated activity increase depends on the presence
of the neuromodulator acetylcholine. Using a spiking network model of visual cortex we have investigated how acetylcholine interacts
with biased feedback to enable attentional processing. Although acetylcholine affects cortical processing in a multitude of manners,
we restricted our analysis to four of its main established actions. These were (i) a reduction in firing rate adaptation by reduction in
M-currents (muscarinic), (ii) an increase in thalamocortical synaptic efficacy by nicotinic presynaptic receptors, (iii) a reduction in
lateral interactions by muscarinic presynaptic receptors, and (iv) an increase in inhibitory drive by muscarinic receptors located on
inhibitory interneurons. We found that acetylcholine contributes to feedback-mediated attentional modulation, mostly by reducing


Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra


Collections: Computer Technologies and Information Sciences