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Summary: MINERAL INDUCED FORMATION OF
PENTOSE-2,4-BISPHOSPHATES
R. KRISHNAMURTHY, S. PITSCH and G. ARRHENIUS
Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA
92093-0220, U.S.A.
(Received 13 April, 1998)
Abstract. Formation of rac.-pentose-2,4-bisphosphates is demonstrated, starting from glycolalde-
hyde phosphate and glyceraldehyde-2-phosphate, and induced by mixed valence double layer metal
hydroxide minerals. The reactions proceed from dilute aqueous reactant solutions (1.5 mM) at near
neutral pH. Conditions have been established, where ribose-2,4-bisphosphate is the major product
(48%) among the pentose-2,4-bisphosphates, which are formed with up to 25% yield.
1. Introduction
Müller, Pitsch et al. (1990) demonstrated that rac.-pentose-2,4-bisphosphates and
hexose-2,4,6-trisphosphates can be formed in basic aqueous solution by aldoliza-
tion of glycolaldehyde phosphate in the presence of formaldehyde with rac.-ribose-
2,4-bisphosphate as the major product in the aldolization mixture. In a collabora-
tive investigation of the ETH and SIO groups it was then found that the formation of
hexose-2,4,6-trisphosphates is induced in the aqueous interlayer of mixed valence
double layer metal hydroxide minerals suspended in more dilute and less basic
solution of glycolaldehyde phosphate (Pitsch et al., 1995). However in the presence
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