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TheJournalofExperimentalMedicine JEM The Rockefeller University Press $30.00
 

Summary: TheJournalofExperimentalMedicine
ARTICLE
JEM © The Rockefeller University Press $30.00
Vol. 205, No. 3, March 17, 2008 557-564 www.jem.org/cgi/doi/
557
10.1084/jem.20080044
Classical nonhomologous DNA end joining
(C-NHEJ), which ligates DNA ends with no
or short stretches of homology, is a major DNA
double-strand break (DSB) repair pathway in
somatic mammalian cells (for review see refer-
ence 1). Known NHEJ factors include Ku70,
Ku80, the DNA­protein kinase catalytic sub-
unit (DNA-PKcs), Artemis, XRCC4, ligase
IV (Lig4), and the recently described XLF/
Cernunnosprotein(1­3).Ku70/Ku80hetero-
dimers bind DSBs and recruit and activate
DNA-PKcs to form the DNA-PK holoenzyme.
With respect to NHEJ, DNA-PKcs autophos-
phorylates and activates the endo/exonuclease

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine