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To define the congruence of human population distribution and P. falciparum transmission we used spatially linked databases of human population, limits of malaria
 

Summary: To define the congruence of human population distribution and P. falciparum
transmission we used spatially linked databases of human population, limits of malaria
risk and malaria endemicity within a Geographic Information System (GIS) as outlined in
detail in Supplementary Information B. In brief, we first defined the spatial extent of
P. falciparum risk by using the mapped global limits of malaria risk provided by the
WHO22
and modified with contemporary descriptions of spatial risk used to inform
antimalarial chemoprophylaxis regimes in travellers22,23
, to exclude the following:
countries with only P. vivax transmission, areas above anopheline vector-specific altitude
limits, and administrative areas defined as risk-free. These boundaries formed the limits
of P. falciparum risk and were overlaid on the only available global map of malaria
endemicity developed in 1968 (refs 6, 7). This map was part of a major synthesis of
historical records, documents and maps of malaria endemicity (using the hypoendemic
to holoendemic classifications) interpolated globally for malaria at the peak of its
assumed historical distribution. We have assumed that this endemicity map is consistent
with contemporary malaria risks in Africa, but development and intervention will have
substantially reduced malaria risk elsewhere11
. Outside the African region we consider
the historical (1968) hyperendemic to holoendemic areas as contemporary (2002)

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collections: Biology and Medicine