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Summary: Journal of Neuroscience Methods 140 (2004) 8192
Exploring the relationship between serotonin and brain-derived
neurotrophic factor: analysis of BDNF protein and
extraneuronal 5-HT in mice with reduced serotonin
transporter or BDNF expression
Matthew E. Szapacsa, Tiffany A. Mathewsa, Lino Tessarolloc,
W. Ernest Lyonsd, Laura A. Mamounase, Anne M. Andrewsa,b,
a Department of Chemistry, The Pennsylvania State University, University Park, PA 16802-4615, USA
b Huck Institute for Life Sciences, The Pennsylvania State University, University Park, PA 16802-4615, USA
c Neural Development Group and Molecular Embryology Section, ABL-Basic Research Program,
National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
d National Institutes of Health/National Institute of Neurological Disorders and Stroke, Scientific Review Branch,
Neuroscience Center, Room 3208, 6001 Executive Blvd MSC 9529, Bethesda, MD 20892-9529, USA
e National Institutes of Health/National Institute of Neurological Disorders and Stroke, Extramural Research Program,
Neuroscience Center, Room 2132, 6001 Executive Blvd MSC 9525, Bethesda, MD 20892-9525, USA
Received 15 December 2003; accepted 10 March 2004
Abstract
Serotonin (5-HT) has been proposed to promote neuronal plasticity during the treatment of mood and anxiety disorders and following
neurodegenerative insult by altering the expression of critical genes including brain-derived neurotrophic factor (BDNF). In this study, mice
with constitutive reductions in the serotonin transporter (SERT) or BDNF were investigated to further assess the functional relationship between
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