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Thyroid Hormone Is an Inhibitor of Estrogen-Induced Degradation of Estrogen Receptor-Protein: Estrogen-
 

Summary: Thyroid Hormone Is an Inhibitor of Estrogen-Induced
Degradation of Estrogen Receptor- Protein: Estrogen-
Dependent Proteolysis Is Not Essential for Receptor
Transactivation Function in the Pituitary
ELAINE T. ALARID, MARA T. PREISLER-MASHEK, AND NATALIA M. SOLODIN
Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706
Proteolysis by the 26S proteasome is an important regulatory
mechanism that governs the protein stability of several
steroid/nuclear receptors and that has been implicated in
the control of receptor transcriptional activation function.
Herein, we report that thyroid hormone can prevent estrogen-
induced proteolysis of estrogen receptor- (ER ) protein in
lactotrope cells of the pituitary. The stabilization of ER pro-
tein by thyroid hormone represents a selective blockade
against estradiol-stimulated degradation, because thyroid
hormone (but not glucocorticoid) can protect estrogen-acti-
vated ER . Moreover, thyroid hormone treatment does not
interfere with signal-induced proteolysis of a separate pro-
teasome target, I B or ER proteolysis induced by ICI182780.
Using thyroid hormone as a tool to inhibit ER proteolysis, we

  

Source: Alarid, Elaine T. - Molecular and Cellular Pharmacology Training Program & Department of Oncology,University of Wisconsin at Madison

 

Collections: Biology and Medicine