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Summary: Microtubule Actin Crosslinking Factor 1 Regulates the
Balbiani Body and Animal-Vegetal Polarity of the
Zebrafish Oocyte
Tripti Gupta1
, Florence L. Marlow1
, Deborah Ferriola2,3,4
, Katarzyna Mackiewicz3,4
, Johannes Dapprich2
,
Dimitri Monos3,4
, Mary C. Mullins1
*
1 Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 2 Generation
Biotech, Lawrenceville, New Jersey, United States of America, 3 Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania,
United States of America, 4 Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of
America
Abstract
Although of fundamental importance in developmental biology, the genetic basis for the symmetry breaking events that
polarize the vertebrate oocyte and egg are largely unknown. In vertebrates, the first morphological asymmetry in the oocyte
is the Balbiani body, a highly conserved, transient structure found in vertebrates and invertebrates including Drosophila,
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