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Summary: REPORT
The incoherent feed-forward loop can generate
non-monotonic input functions for genes
Shai Kaplan1,2,3
, Anat Bren1,3
, Erez Dekel1
and Uri Alon1,
*
1
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel and 2
Department of Biological Chemistry, Weizmann Institute of Science,
Rehovot, Israel
3
These authors contributed equally to this work
* Corresponding author. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel. Tel.: þ 972 893 444 48; Fax: þ 972 893 441 25;
E-mail: urialon@wisemail.weizmann.ac.il
Received 4.1.08; accepted 30.5.08
Gene regulation networks contain recurring circuit patterns called network motifs. One of the most
common network motif is the incoherent type 1 feed-forward loop (I1-FFL), in which an activator
controls both gene and repressor of that gene. This motif was shown to act as a pulse generator and
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