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Nature GeNetics VOLUME 42 | NUMBER 11 | NOVEMBER 2010 991 Psoriasisisamultifactorialskindiseasecharacterizedby
 

Summary: Nature GeNetics VOLUME 42 | NUMBER 11 | NOVEMBER 2010 991
Psoriasisisamultifactorialskindiseasecharacterizedby
epidermalhyperproliferationandchronicinflammation,
themostcommonformofwhichispsoriasisvulgaris(PsV).
Wepresentagenome-wideassociationanalysisof2,339,118
SNPsin472PsVcasesand1,146controlsfromGermany,
withfollow-upofthe147mostsignificantSNPsin2,746PsV
casesand4,140controlsfromthreeindependentreplication
panels.WeidentifiedanassociationatTRAF3IP2on6q21and
genotypedtwoSNPsatthislocusintwoadditionalreplication
panels(thecombineddiscoveryandreplicationpanelsconsisted
of6,487casesand8,037controls;combinedP=2.3610-10
forrs13210247andcombinedP=1.2410-16forrs33980500).
About15%ofpsoriasiscasesdeveloppsoriaticarthritis(PsA).
AstratifiedanalysisofourdatasetsincludingonlyPsAcases
(1,922casescomparedto8,037controls,P=4.5710-12
forrs33980500)suggestedthatTRAF3IP2representsashared
susceptibilityforPsVandPsA.TRAF3IP2encodesaprotein
involvedinIL-17signalingandwhichinteractswithmembers
oftheRel/NF-Btranscriptionfactorfamily.

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

 

Collections: Biology and Medicine; Mathematics