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Journal of Clinical Immunology, Vol. 26, No. 2, March 2006 (C 2006) DOI: 10.1007/s10875-006-9001-y
 

Summary: Journal of Clinical Immunology, Vol. 26, No. 2, March 2006 (C 2006)
DOI: 10.1007/s10875-006-9001-y
Increased Apoptosis of CD20+ IgA+ B Cells is the Basis for IgA
Deficiency: The Molecular Mechanism
for Correction In Vitro by IL-10 and CD40L
ZAHEED HUSAIN,1,3
NICHOL HOLODICK,1
CAITLIN DAY,1
IRMA SZYMANSKI,2
and CHESTER
A. ALPER1,4,5
Received August 2, 2005; accepted October 24, 2005
Published online: 26 April 2006
IgA deficiency is the most common primary immunodefi-
ciency in humans. Comparative analysis of gene expression
in PBMC from IgA-deficient (IgAd) and normal donors us-
ing functional multiplex panels showed overexpression of the
Caspase-1 (CASP-1) gene. Cells from all the IgAd donors (n = 7)
expressed 410-fold caspase-1 mRNA over normal controls
(n = 5). CD19+

  

Source: Alper, Chester A. - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine