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Integrated measurement system for simultaneous functional magnetic resonance imaging and diffuse optical tomography in human brain mapping
 

Summary: Integrated measurement system for simultaneous functional magnetic
resonance imaging and diffuse optical tomography in human brain mapping
Xiaofeng Zhang
Department of Bioengineering, Pennsylvania State University, University Park, Pennsylvania 16802
Vladislav Y. Toronov
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign,
Urbana, Illinois 61801
Andrew G. Webba
Department of Bioengineering, Pennsylvania State University, University Park, Pennsylvania 16802
Received 18 June 2006; accepted 28 August 2006; published online 15 November 2006
An integrated measurement system has been developed for performing simultaneous functional
magnetic resonance imaging fMRI and diffuse optical tomography DOT for human brain
mapping experiments. The components of this system consist of a MRI-compatible
multioverlapping-channel near-infrared NIR optical probe, techniques for accurate and reliable
coregistration of optical and fMRI results, and an optical image reconstruction algorithm with
structural and physiological constraints derived from the MRI data. The optical probe is fully MRI
compatible in that it produces negligible MR image distortion and does not require any modification
to the MRI scanner or data acquisition protocols. This probe can be attached to virtually any part of
the head without imposing limits on optical data acquisition. Coregistration of images from fMRI
and optical measurements is achieved by localizing the positions of the optical fibers using MRI

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine