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r XXXX American Chemical Society A dx.doi.org/10.1021/la202430m |Langmuir XXXX, XXX, 000000 pubs.acs.org/Langmuir
 

Summary: r XXXX American Chemical Society A dx.doi.org/10.1021/la202430m |Langmuir XXXX, XXX, 000000
LETTER
pubs.acs.org/Langmuir
Cross-Linked, Heterogeneous Colloidosomes Exhibit pH-Induced
Morphogenesis
Jin-Oh You, Marjan Rafat, and Debra T. Auguste*
School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States
' INTRODUCTION
Morphogenesis is the process by which an organism changes
shape, where networks of individual units collectively respond to
chemical or mechanical cues to alter their form.1,2
At the mole-
cular level, integrins undergo dramatic conformational changes
to achieve a high-affinity configuration during the process of
integrin activation. Integrin activation can be regulated by
intracellular and extracellular signals, including the extracellular
pH, which becomes acidic in several biological contexts. Whereas
normal physiological pH is 7.4, the average extracellular pH in
the tumor environment ranges between 6.2 and 6.9.36
During

  

Source: Auguste, Debra T. - School of Engineering and Applied Sciences, Harvard University

 

Collections: Materials Science; Biology and Medicine