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Copyright 2010 by the Genetics Society of America DOI: 10.1534/genetics.110.116863
 

Summary: Copyright 2010 by the Genetics Society of America
DOI: 10.1534/genetics.110.116863
Genome-Wide Association Studies and the Problem of Relatedness Among
Advanced Intercross Lines and Other Highly Recombinant Populations
Riyan Cheng,* Jackie E. Lim,
Kaitlin E. Samocha,* Greta Sokoloff,* Mark Abney,*
Andrew D. Skol
and Abraham A. Palmer*,,1
*Department of Human Genetics,
Department of Medicine, Section for Genetic Medicine and
Department of Psychiatry
and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637 and
Pharmacology and Cancer
Biology of Duke University Medical Center, Durham, North Carolina 27710
Manuscript received March 22, 2010
Accepted for publication April 14, 2010
ABSTRACT
Model organisms offer many advantages for the genetic analysis of complex traits. However,
identification of specific genes is often hampered by a lack of recombination between the genomes of
inbred progenitors. Recently, genome-wide association studies (GWAS) in humans have offered gene-level

  

Source: Abney, Mark - Department of Human Genetics, University of Chicago
Das, Soma - Department of Human Genetics, University of Chicago
Ober, Carole - Committee on Genetics & Department of Human Genetics, University of Chicago

 

Collections: Biology and Medicine; Computer Technologies and Information Sciences