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Summary: Copyright Ó 2010 by the Genetics Society of America
DOI: 10.1534/genetics.110.116863
Genome-Wide Association Studies and the Problem of Relatedness Among
Advanced Intercross Lines and Other Highly Recombinant Populations
Riyan Cheng,* Jackie E. Lim,
Kaitlin E. Samocha,* Greta Sokoloff,* Mark Abney,*
Andrew D. Skol
and Abraham A. Palmer*,§,1
*Department of Human Genetics,
Department of Medicine, Section for Genetic Medicine and §
Department of Psychiatry
and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637 and
Pharmacology and Cancer
Biology of Duke University Medical Center, Durham, North Carolina 27710
Manuscript received March 22, 2010
Accepted for publication April 14, 2010
ABSTRACT
Model organisms offer many advantages for the genetic analysis of complex traits. However,
identification of specific genes is often hampered by a lack of recombination between the genomes of
inbred progenitors. Recently, genome-wide association studies (GWAS) in humans have offered gene-level
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