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21 DECEMBER 2007 VOL 318 SCIENCE www.sciencemag.org1844 CREDITS(TOPTOBOTTOM):UNIVERSITYOFWISCONSIN,MADISON;TERRYSMITH(CRYSTALBALLS)
 

Summary: 21 DECEMBER 2007 VOL 318 SCIENCE www.sciencemag.org1844
CREDITS(TOPTOBOTTOM):UNIVERSITYOFWISCONSIN,MADISON;TERRYSMITH(CRYSTALBALLS)
Breakthrough of the Year
REPROGRAMMING CELLS. TheriddleofDolly
the Sheep has puzzled biologists for more than a decade:
What is it about the oocyte that rejuvenates the nucleus of a
differentiatedcell,promptingthegenometoreturntotheembryonicstate
and form a new individual? This
year, scientists came closer to solv-
ing that riddle. In a series of papers,
researchers showed that by adding
just a handful of genes to skin cells,
they could reprogram those cells to
look and act like embryonic stem
(ES) cells. ES cells are famous for
their potential to become any kind
of cell in the body. But because
researchers derive them from early
embryos, they are also infamous for
the political and ethical debates that

  

Source: Addis, Donna Rose - Department of Psychology, University of Auckland

 

Collections: Biology and Medicine