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A One-Pot, Microwave-Influenced Synthesis of Diverse Small Molecules by Multicomponent Reaction Cascades
 

Summary: A One-Pot, Microwave-Influenced Synthesis of Diverse Small Molecules by
Multicomponent Reaction Cascades
Soumava Santra and Peter R. Andreana*
Department of Chemistry,
Wayne State University,
5101 Cass Ave,
Detroit, MI 48202
Supporting Information
Materials and Methods: All reagents were purchased from Aldrich unless otherwise
mentioned. 4-Hydroxybenzylamine was purchased from Matrix Scientific. 4-Hydroxy-
3-methoxybenzylamine hydrochloride was purchased from Alfa Aesar. Except as
otherwise indicated, reactions were carried out under argon. Microwave reactions were
conducted in a capped vial using a CEM Discover System. All reactions were monitored
using thin layer chromatography on 0.25 mm Dynamic Adsorbents, L.L.C. precoated
silica gel (particle size 0.03-0.07 mm, catalog no. 84111, lot # LA2006). Column
chromatography was performed using Whatman Purasil 60 (230-400 mesh ASTM)
silica gel. Yields refer to chromatographically and spectroscopically pure compounds
except where noted in the manuscript (Table 1). Diastereomeric ratios were determined
from 1
H NMR spectra of unquenched reactions. Proton and carbon-13 NMR spectra

  

Source: Andreana, Peter R. - Department of Chemistry, Wayne State University

 

Collections: Chemistry