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Genomic and proteomic approaches to the identifica-tion of new targets for drug intervention present

Summary: REVIEWS
Genomic and proteomic approaches to the identifica-
tion of new targets for drug intervention present
unprecedented opportunities for the discovery of new
agents with novel therapeutic modes of action1
Nevertheless, some daunting difficulties and risks will
need to be overcome to realize this potential.
Historically,the proteins that the pharmaceutical indus-
try has targeted for drug discovery have generally been
well understood from a mechanistic and biological
standpoint. By contrast, relatively little or nothing
might be known about the mechanism or biological
function of a`genomics'target,which might be rendered
interesting in the first instance simply by virtue of its
appearance in a disease context or apparent effects in a
shotgun gene-knockout experiment. So, genomics-
based target discovery is typically followed by a laborious
process of target validation, which generally produces
useful, although often ambiguous, information about


Source: Agrafiotis, Dimitris K. - Molecular Design and Informatics Group, Johnson & Johnson Pharmaceutical Research and Development


Collections: Chemistry; Computer Technologies and Information Sciences