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Chloride Channels Myles H Akabas,Columbia University, New York, USA

Summary: Chloride Channels
Myles H Akabas,Columbia University, New York, USA
Chloride channels are integral membrane proteins whose functions are to regulate the
movement of chloride ions across cellular membranes. They perform a vital role in
physiological processes such as cell volume regulation, epithelial transport, the regulation
of nerve and muscle cell membrane excitability and in determining the pH within
cytoplasmic membrane-bound organelles.
Ion channels are integral membrane proteins that form
ion-selective, water-filled pores across cellular membranes.
Chloride channels are a subset of ion channels that are
selectively permeable to chloride and often to other small
monovalent anions. Chloride channels are found in the
plasma membranes of most cells and in the membranes of
various intracellular organelles including the endoplasmic
reticulum, Golgi apparatus, endosomes and sarcoplasmic
reticulum. The physiological functions of chloride chan-
nels include stabilization of resting membrane potentials in
muscle and nerve cells, transepithelial transport, cell
volume regulation, signal transduction and acidification


Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University


Collections: Biology and Medicine