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Dynamics of multiple symbiont density regulation during host development: tsetse

Summary: Dynamics of multiple symbiont density
regulation during host development: tsetse
fly and its microbial flora
Rita V. M. Rio
, Yi-neng Wu, Giovanni Filardo,
and Serap Aksoy*
Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street,
606 LEPH, New Haven CT 06510, USA
Symbiotic associations often enhance hosts' physiological capabilities, allowing them to expand into
restricted terrains, thus leading to biological diversification. Stable maintenance of partners is essential for
the overall biological system to succeed. The viviparous tsetse fly (Diptera: Glossinidae) offers an
exceptional system to examine factors that influence the maintenance of multiple symbiotic organisms
within a single eukaryotic host. This insect harbours three different symbionts representing diverse
associations, coevolutionary histories and transmission modes. The enterics, obligate mutualist
Wigglesworthia and beneficial Sodalis, are maternally transmitted to the intrauterine larvae, while parasitic
Wolbachia infects the developing oocyte. In this study, the population dynamics of these three symbionts
were examined through host development and during potentially disruptive events, including host immune
challenge, the presence of third parties (such as African trypanosomes) and environmental perturbations
(such as fluctuating humidity levels). While mutualistic partners exhibited well-regulated density profiles
over different host developmental stages, parasitic Wolbachia infections varied in individual hosts. Host


Source: Aksoy, Serap - School of Public Health, Yale University
Wells, Jeffrey D. - Department of Biology, West Virginia University


Collections: Biology and Medicine