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Summary: Our recent fMRI studies indicate that
spontaneous chronic back-pain (CBP) is
associated with sustained activity in
medial prefrontal cortex (mPFC), while
thermal acute pain is associated with
more parietal sensory and rostral
cingulate activity. In this study, we
examine brain activity related to
spontaneous fluctuations of ongoing
pain in post-herpetic neuropathy (PHN),
using fMRI, and we contrast this activity
pattern with that of spontaneous CBP,
and acute thermal pain in normal
subjects.
INTRODUCTION
11 PHN patients were studied with fMRI
for spontaneous (stimulus independent)
pain. All patients reported a history of
PHN pain for at least 3 months after the
resolution of the rash.
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