| | |
Summary: 11
We used spared nerve injury (SNI) model to assess
effects of sarcosine in adult, male, Sprague Dawley
rats. Tactile thresholds were assessed using Von
Frey filaments. Cold allodynia (acetone test) and
motor abilities (open field) were also tested. All
measures were done blinded.
Treatments:
· Acute oral doses (Sarcosine or Saline; 50, 250 and
500 g/kg, 2 ml/kg)
· Acute intrathecal injections (Sarcosine or Saline;
50g, 10l/site)
· Acute brain infusions in mPFC (Sarcosine or
Saline; 50g, 0.5l/site)
· Chronic oral doses: rats were treated twice a day
orally for 14 consecutive days (Sarcosine or Saline;
250g/kg, 2 ml/kg). Response time course was
followed during treatment and 14 days after
cessation of treatment.
For brain infusions rats were anesthetized and
|
