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Summary: ©2011NatureAmerica,Inc.Allrightsreserved.
nature structural & molecular biology advance online publication
b r i e F com mu n i cat i on s
Crystal structure of a monomeric
retroviral protease solved by
protein folding game players
Firas Khatib1, Frank DiMaio1, Foldit Contenders Group, Foldit Void
CrushersGroup,SethCooper2,MaciejKazmierczyk3,MiroslawGilski3,4,
Szymon Krzywda3, Helena Zabranska5, IvaPichova5,JamesThompson1,
Zoran Popovi2, Mariusz Jaskolski3,4 & David Baker1,6
Following the failure of a wide range of attempts to solve the
crystal structure of M-PMV retroviral protease by molecular
replacement, we challenged players of the protein folding game
Foldit to produce accurate models of the protein. Remarkably,
Foldit players were able to generate models of sufficient quality
for successful molecular replacement and subsequent structure
determination. The refined structure provides new insights for
the design of antiretroviral drugs.
Foldit is a multiplayer online game that enlists players worldwide to
solve difficult protein-structure prediction problems. Foldit players
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