Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network

  Advanced Search  

2011NatureAmerica,Inc.Allrightsreserved. nature structural & molecular biology advance online publication

Summary: 2011NatureAmerica,Inc.Allrightsreserved.
nature structural & molecular biology advance online publication
b r i e F com mu n i cat i on s
Crystal structure of a monomeric
retroviral protease solved by
protein folding game players
Firas Khatib1, Frank DiMaio1, Foldit Contenders Group, Foldit Void
Szymon Krzywda3, Helena Zabranska5, IvaPichova5,JamesThompson1,
Zoran Popovi2, Mariusz Jaskolski3,4 & David Baker1,6
Following the failure of a wide range of attempts to solve the
crystal structure of M-PMV retroviral protease by molecular
replacement, we challenged players of the protein folding game
Foldit to produce accurate models of the protein. Remarkably,
Foldit players were able to generate models of sufficient quality
for successful molecular replacement and subsequent structure
determination. The refined structure provides new insights for
the design of antiretroviral drugs.
Foldit is a multiplayer online game that enlists players worldwide to
solve difficult protein-structure prediction problems. Foldit players


Source: Anderson, Richard - Department of Computer Science and Engineering, University of Washington at Seattle
Baker, David - Center for Nanotechnology and NanoTechnology & Department of Biochemistry, University of Washington at Seattle


Collections: Biotechnology; Chemistry; Computer Technologies and Information Sciences