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DEVELOPMENTALBIOLOGY 152,411-414 (19%) Fibroblast Growth Factor Receptors Contain a Conserved HAV Region
 

Summary: DEVELOPMENTALBIOLOGY 152,411-414 (19%)
Fibroblast Growth Factor Receptors Contain a Conserved HAV Region
Common to Cadherins and Influenza Strain A Hemagglutinins:
A Role in Protein-Protein Interactions?
*Depcrrtmenf of Anufomy and Cell Biology and the Lombardi Cancer Center, Georgetown UGversity Medicul Ceellter,Wash&&n D.C. 10007;
tDepartment of Biochemistry urd Biophysics, School of Medicine, University of California, San Francisco, Sun Francisco, Cal$ornia 9f+1&0448;
and $Division of Urology, Department of Sztrgery, McGill University and the Royal Victoria Hospital. Montreal, P.Q. H&4 1.41.Canada
Accepted April 2, 1992
The lirst extracellular domain of the cadherins has been shown to exhibit extensive sequence homology with the
amino termini of the HA1 chains of influenza strain A hemagglutinins. These regions of homology are known to be
functionally important in both the cadherins and the hemagglutinins. The homologous regions harbor the tripeptidc
HAL', which has been identified as being the cadherin cell adhesion recognition sequence. Here we report that members
of the rapidly expanding family of fibroblast growth factor receptors also possess HAV-containing regions. These
regions are homologous to the HAV-containing regions present within both the hemagglutinins and the cadherins and
appear to be involved in regulating the function of the fibroblast growth factor receptors. We speculate that the HAV
motif may represent an evolutionarily conserved amino acid sequence that will prove to be functionally important in a
wide variety of proteins. 6 1992 Academic Press, Inc
INTRODUCTION
The cadherins are a family of integral membrane gly-
coproteins that mediate calcium dependent cell-cell ad-

  

Source: Amaya, Enrique - Healing Foundation Centre & Developmental Biology, Faculty of Life Sciences, University of Manchester

 

Collections: Biology and Medicine