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Summary: Gene Expression Profiles of Nondiabetic and Diabetic
Obese Mice Suggest a Role of Hepatic Lipogenic
Capacity in Diabetes Susceptibility
Hong Lan,1
Mary E. Rabaglia,1
Jonathan P. Stoehr,1
Samuel T. Nadler,1
Kathryn L. Schueler,1
Fei Zou,2
Brian S. Yandell,3
and Alan D. Attie1
Obesity is a strong risk factor for the development of
type 2 diabetes. We have previously reported that in
adipose tissue of obese (ob/ob) mice, the expression of
adipogenic genes is decreased. When made genetically
obese, the BTBR mouse strain is diabetes susceptible
and the C57BL/6J (B6) strain is diabetes resistant. We
used DNA microarrays and RT-PCR to compare the gene
expression in BTBR-ob/ob versus B6-ob/ob mice in adi-
pose tissue, liver, skeletal muscle, and pancreatic islets.
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