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2003 The Society for the Study of Evolution. All rights reserved. Evolution, 57(7), 2003, pp. 14891497
 

Summary: 1489
2003 The Society for the Study of Evolution. All rights reserved.
Evolution, 57(7), 2003, pp. 1489­1497
WITHIN-HOST PARASITE DYNAMICS, EMERGING TRADE-OFF, AND EVOLUTION OF
VIRULENCE WITH IMMUNE SYSTEM
JEAN-BAPTISTE ANDRE´ ,1,2 JEAN-BAPTISTE FERDY,1,3 AND BERNARD GODELLE1,4
1Laboratoire Ge´nome, Populations, Interactions, Adaptation, UM2-IFREMER-CNRS UMR 5000,
Universite´ Montpellier II-CC 063, Ba^timent 13, RdC, Place Euge`ne Bataillon, 34095 Montpellier Cedex 5, France
2E-mail: jbandre@crit.univ-montp2.fr
3E-mail: ferdy@crit.univ-montp2.fr
4E-mail: godelle@crit.univ-montp2.fr
Abstract. Virulence is an evolutionary paradox because parasites never benefit from their host's death. The adaptive
explanation of virulence is classically based upon the existence of physiological constraints that create a trade-off
between parasites' epidemiological traits (virulence, transmissibility, and clearance). Here we develop an epidemio-
logical model where infections are dynamic processes and we demonstrate how these dynamics generate a trade-off
between emerging epidemiological parameters. We then study how host's immune strength modifies this trade-off
and hence influences virulence evolution. We found that in acute infections, where parasites are engaged in a race
with immune cells, immunity restrains more the duration of the infection than its intensity. As a consequence parasites
evolve to provoke more virulent but shorter infections in strongly immunized hosts.
Key words. Acute infections, evolution of virulence, microparasites, specific immunity, trade-off, within-host models.

  

Source: André, Jean-Baptiste - CNRS & Université Pierre-et-Marie-Curie, Paris 6
Caraco, Thomas - Department of Biological Sciences, State University of New York at Albany

 

Collections: Biology and Medicine; Environmental Sciences and Ecology