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Control of cell polarity and mitotic spindle positioning in animal cells

Summary: Control of cell polarity and mitotic spindle positioning
in animal cells
Julie Ahringer
Cell polarity is an essential feature of many animal cells. It is
critical for epithelial formation and function, for correct
partitioning of fate-determining molecules, and for individual
cells to chemotax or grow in a deŽned direction. For some of
these processes, the position and orientation of the mitotic
spindle must be coupled to cell polarity for correct positioning of
daughter cells and inheritance of localised molecules. Recent
work in several different systems has led to the realisation that
similar mechanisms dictate the establishment of polarity and
subsequent spindle positioning in many animal cells.
Microtubules and conserved PAR proteins are essential
mediators of cell polarity, and mitotic spindle positioning
depends on heterotrimeric G protein signalling and the
microtubule motor protein dynein.
Wellcome Trust/Cancer Research UK Institute, Tennis Court Road,
Cambridge CB2 1QR, UK


Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge


Collections: Biology and Medicine