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Summary: Fold-change detection and scalar symmetry of
sensory input fields
Oren Shovala
, Lea Goentorob
, Yuval Harta
, Avi Mayoa
, Eduardo Sontagc
, and Uri Alona,1
a
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; b
Department of Systems Biology, Harvard Medical School,
Boston, MA 02115; and c
Department of Mathematics, Rutgers University, Piscataway, NJ 08854
Edited by Curtis G. Callan, Princeton University, Princeton, NJ, and approved July 2, 2010 (received for review February 26, 2010)
Recent studies suggest that certain cellular sensory systems display
fold-change detection (FCD): a response whose entire shape, in-
cluding amplitude and duration, depends only on fold changes in
input and not on absolute levels. Thus, a step change in input from,
for example, level 1 to 2 gives precisely the same dynamical output
as a step from level 2 to 4, because the steps have the same fold
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