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Available online at www.sciencedirect.com Microtubule assembly dynamics: new insights at the nanoscale
 

Summary: Available online at www.sciencedirect.com
Microtubule assembly dynamics: new insights at the nanoscale
Melissa K Gardner1
, Alan J Hunt2
, Holly V Goodson3
and David J Odde1
Although the dynamic self-assembly behavior of microtubule
ends has been well characterized at the spatial resolution of
light microscopy (200 nm), the single-molecule events that
lead to these dynamics are less clear. Recently, a number of in
vitro studies used novel approaches combining laser tweezers,
microfabricated chambers, and high-resolution tracking of
microtubule-bound beads to characterize mechanochemical
aspects of MT dynamics at nanometer scale resolution. In
addition, computational modeling is providing a framework for
integrating these experimental results into physically plausible
models of molecular scale microtubule dynamics. These
nanoscale studies are providing new fundamental insights
about microtubule assembly, and will be important for
advancing our understanding of how microtubule dynamic

  

Source: Asbury, Chip - Department of Physiology and Biophysics, University of Washington at Seattle

 

Collections: Biology and Medicine