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The Notch ligand Jagged1 is required for inner ear sensory development
 

Summary: The Notch ligand Jagged1 is required for inner ear
sensory development
Amy E. Kiernan*
, Nadav Ahituv
, Helmut Fuchs§
, Rudi Balling¶
, Karen B. Avraham
, Karen P. Steel* ,
and Martin Hrabe´ de Angelis§
*Medical Research Council Institute of Hearing Research, University Park, Nottingham NG7 2RD, United Kingdom; Department of Human Genetics and
Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel; §GSF Center of Environment and
Health Institute of Experimental Genetics, Neuherberg, Postfach 1129, Oberschleissheim, 85758, Germany; and ¶GSF Center of
Environment and Health Institute of Mammalian Genetics, Neuherberg, Postfach 1129, Oberschleissheim, 85758, Germany
Edited by Shirley M. Tilghman, Princeton University, Princeton, NJ, and approved January 26, 2001 (received for review October 19, 2000)
Within the mammalian inner ear there are six separate sensory
regions that subserve the functions of hearing and balance, al-
though how these sensory regions become specified remains
unknown. Each sensory region is populated by two cell types, the
mechanosensory hair cell and the supporting cell, which are ar-
ranged in a mosaic in which each hair cell is surrounded by

  

Source: Avraham, Karen - Department of Human Genetics and Molecular Medicine, Tel Aviv University

 

Collections: Biology and Medicine