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Advances in the study of Drosophila melanogaster and Caenorhabditis elegans have provided key insights into the
 

Summary: 499
Advances in the study of Drosophila melanogaster and
Caenorhabditis elegans have provided key insights into the
processes of neurotransmission and neuromodulation. Work in
the past year has revealed that Unc-13 and Rab3a-interacting
molecule regulate the conformational state of syntaxin to prime
synaptic vesicle fusion. Analyses of synaptotagmin support its
role as a putative calcium sensor triggering vesicular fusion and
highlight the possible role of SNARE complex oligomerization in
the fusion mechanism. Characterization of endophilin mutants
demonstrates that kiss-and-run endocytosis is a major
component of synaptic vesicle recycling. In neuromodulation,
dcaps mutants provide the first genetic insight into possible
roles of the CAPS protein in mediating dense core vesicle
fusion and modulating synaptic vesicle fusion.
Addresses
*Department of Biological Sciences, University of Illinois,
840 West Taylor Street, Chicago, Illinois 60607, USA
Department of Biological Sciences, Vanderbilt University,
4270 Medical Research Building III, 465 21st Avenue South,

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collections: Biology and Medicine