| | |
Summary: Mechanism and Control of V(D)J Recombination versus Class
Switch Recombination: Similarities and Differences
Darryll D. Dudley,1
Jayanta Chaudhuri,
Craig H. Bassing, and Frederick W. Alt
Howard Hughes Medical Institute, The Children's Hospital Boston,
CBR Institute for Biomedical Research, and Harvard Medical School,
Boston, Massachusetts 02115
Abstract .................................................................................................. 43
1. Overview: V(D)J and Class Switch Recombination ............................................... 44
2. Antigen Receptor Gene Rearrangement............................................................ 47
3. Regulation of V(D)J Recombination ................................................................ 61
4. Class Switch Recombination Employs Distinct Mechanisms
for V(D)J Recombination ............................................................................. 69
5. CSR-Related Diseases ................................................................................. 93
6. Concluding Remarks................................................................................... 95
References............................................................................................... 97
Abstract
V(D)J recombination is the process by which the variable region exons encoding
the antigen recognition sites of receptors expressed on B and T lymphocytes are
|
