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Summary: HLA-Cw7 Zygosity Affects the Size of a Subset of CD158b
Natural Killer Cells
ZAHEED HUSAIN,1,3
EDWARD LEVITAN,1
CHARLES E. LARSEN,2,4
NADEEM M. MIRZA,1
SOUHAD YOUNES,1
EDMOND J. YUNIS,1,3
CHESTER A. ALPER,2,5
and DEVENDRA P. DUBEY2,6
Accepted: September 27, 2001
Individuals with certain HLA class I genotypes are highly
susceptible to disease after viral infection. Natural killer (NK)
cells kill virus-infected cells through a mechanism involving
HLA class I receptors. These facts may be connected if an
individual's HLA genotype regulates the number and function
of NK cells. We have observed that subjects homozygous for
the HLA-B/C region of conserved major histocompatibility
complex (MHC) extended haplotypes have lower NK cell
activity and a significantly lower frequency of CD16 CD56
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