Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network

  Advanced Search  

Constraint-based network model of pathogenimmune system interactions

Summary: Constraint-based network model of
pathogen­immune system interactions
Juilee Thakar1
, Assieh Saadatpour-Moghaddam2
, Eric T. Harvill3
and Re´ka Albert1,*
Department of Physics, 104 Davey Laboratory, 2
Department of Mathematics, 109 McAllister
Building, and 3
Department of Veterinary and Biomedical Sciences, 115 Henning Building,
Pennsylvania State University, University Park, PA 16802, USA
Pathogenic bacteria such as Bordetella bronchiseptica modulate host immune responses to
enable their establishment and persistence; however, the immune response is generally
successful in clearing these bacteria. Here, we model the dynamic outcome of the interplay
between host immune components and B. bronchiseptica virulence factors. The model
extends our previously published interaction network of B. bronchiseptica and includes the
existing experimental information on the relative timing of IL10 and IFNg activation in the
form of qualitative inequalities. The current model improves the previous one in two
directions: (i) by augmenting the network with new nodes with specific function in T helper


Source: Albert, Réka - Departments of Biology & Physics, Pennsylvania State University
Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University
Thakar, Julie - Department of Physics, Pennsylvania State University


Collections: Biology and Medicine; Physics