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Functional comparison of RGS9 splice isoforms in a living cell

Summary: Functional comparison of RGS9 splice isoforms
in a living cell
Kirill A. Martemyanova,b
, Claudia M. Krispelc,d
, Polina V. Lishkoa
, Marie E. Burnsc,d,1
, and Vadim Y. Arshavskya,e,1
aDepartment of Ophthalmology, Harvard Medical School, Boston, MA 02114; bDepartment of Pharmacology, University of Minnesota, Minneapolis,
MN 55455; cCenter for Neuroscience and dDepartment of Ophthalmology & Vision Science, University of California, Davis, CA 95618;
and eDepartments of Ophthalmology and Pharmacology, Duke University, Durham, NC 27710
Edited by Jeremy Nathans, Johns Hopkins University School of Medicine, Baltimore, MD, and approved November 10, 2008 (received for review
September 9, 2008)
Two isoforms of the GTPase-activating protein, regulator of G
protein signaling 9 (RGS9), control such fundamental functions as
vision and behavior. RGS91 regulates phototransduction in rods
and cones, and RGS92 regulates dopamine and opioid signaling
in the basal ganglia. To determine their functional differences in
the same intact cell, we replaced RGS91 with RGS92 in mouse
rods. Surprisingly, RGS92 not only supported normal photore-
sponse recovery under moderate light conditions but also outper-


Source: Arshavsky, Vadim Y. - Department of Pharmacology, Duke University


Collections: Biology and Medicine