Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network

  Advanced Search  

Consolidation of CS and US Representations in Associative Fear Conditioning

Summary: Consolidation of CS and US Representations
in Associative Fear Conditioning
Paul W. Frankland, Sheena A. Josselyn, Stephan G. Anagnostaras, Jeffrey H. Kogan,
Eiki Takahashi, and Alcino J. Silva*
ABSTRACT: Much attention has been paid to the associative processes
that are necessary to fuse together representations of the various compo-
nents of an episodic memory. In the present study, we focus on the
processes involved in the formation of lasting representations of the
individual components that make up a fear-conditioning episode. In one-
trial contextual fear conditioning experiments, weak conditioning to con-
text occurs if the shock is delivered immediately following placement of
the animal in a novel conditioning apparatus, a phenomenon known as the
immediate shock deficit. We show that the immediate shock deficit in
mice may be alleviated by pre-exposure to either the context or shock. In
using this approach to temporally dissect a contextual fear-conditioning
task into its constituent representational and associative processes, we are
able to examine directly the processes that are important for formation of
lasting representations of the context conditioned stimulus (CS) or uncon-
ditioned stimulus (US). Our data indicate that the formation of a lasting
representation of the context or shock engages protein synthesis-depen-


Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego
Silva, Alcino - Department of Neurobiology, University of California at Los Angeles


Collections: Biology and Medicine