 
Summary: UNCORRECTED
PROOF
MCM: 2825 + Model pp. 112 (col. fig: NIL)
ARTICLE IN PRESS
Mathematical and Computer Modelling xx (xxxx) xxxxxx
www.elsevier.com/locate/mcm
A simplified model for growth factor induced healing of wounds
F.J. Vermolena,, E. van Baarena, J.A. Adamb
a Delft University of Technology, Department of Applied Mathematics, Mekelweg 4, 2628 CD Delft, The Netherlands
b Old Dominion University, Department of Mathematics and Statistics, Norfolk, VA 235290077, USA
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Abstract 3
A mathematical model is developed for the rate of healing of a circular or elliptic wound. In this paper the regeneration, decay 4
and transport of a generic `growth factor', which induces the healing of the wound, is taken into account. Further, an equation of 5
motion is derived for radial healing of a circular wound. The expressions for the equation of motion and the distribution of the 6
growth factor are related in such a way that no healing occurs if the growth factor concentration at the wound edge is below a 7
threshold value. In this paper we investigate the influence of the behaviour of the thickness of the active layer, in which the growth 8
factor is produced, on the healing process. Also a correction is made to a result in earlier work. 9
c 2006 Published by Elsevier Ltd 10
