Summary: Characterization and functional divergence of the 1-adrenoceptor gene
family: insights from rainbow trout (Oncorhynchus mykiss)
Xi Chen,1
Steve F. Perry,1
Ste´phane Aris-Brosou,1,2
Corrado Selva,1
and Thomas W. Moon1
1
Department of Biology and Centre for Advanced Research in Environmental Genomics, 2
Department of Mathematics and
Statistics, University of Ottawa, Ottawa, Ontario, Canada
Submitted 22 November 2006; accepted in final form 10 October 2007
Chen X, Perry SF, Aris-Brosou S, Selva C, Moon TW. Charac-
terization and functional divergence of the 1-adrenoceptor gene
family: insights from rainbow trout (Oncorhynchus mykiss). Physiol
Genomics 32: 142­153, 2007. First published October 16, 2007;
doi:10.1152/physiolgenomics.00258.2006.--Presently, three 1-adre-
noceptor (AR) types are recognized in vertebrates: 1A-, 1B-, and
1D-ARs. These 1-subtypes have distinct pharmacology and molec-
ular profiles, play crucial roles in metabolic and vascular control, and

Source: Aris-Brosou, Stéphane - Department of Biology, University of Ottawa

Collections: Biology and Medicine