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PHYSICAL REVIEW E 84, 031929 (2011) Network analysis reveals cross-links of the immune pathways activated by bacteria and allergen
 

Summary: PHYSICAL REVIEW E 84, 031929 (2011)
Network analysis reveals cross-links of the immune pathways activated by bacteria and allergen
Colin Campbell,1,*
Juilee Thakar,2,
and R´eka Albert1,3,
1
Department of Physics, Pennsylvania State University, University Park, Pennsylvania 16803, USA
2
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06511, USA
3
Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16803, USA
(Received 26 April 2011; published 28 September 2011)
Many biological networks are characterized by directed edges that represent either activating (positive) or
inhibiting (negative) regulation. Most graph-theoretical methods used to study biological networks either disregard
this important feature, or study the role of edge sign only in the context of small subgraphs called motifs. Here, we
develop path-based measures which capture, on continuous scales spanning negative and positive values, both the
long- and short-range regulatory relationships among node pairs. These measures also allow the quantification of
each node's overall influence on the whole network and its susceptibility to regulation by the rest of the network.
We apply the measures to a network representation of the mammalian immune response to simultaneous attack
by allergen and respiratory bacteria. Although allergen and bacteria elicit different immune pathways, there is

  

Source: Albert, Réka - Departments of Biology & Physics, Pennsylvania State University

 

Collections: Biology and Medicine