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Copyright 2000 by the Genetics Society of America Genetic Analysis of the Drosophila 63F Early Puff: Characterization of
 

Summary: Copyright 2000 by the Genetics Society of America
Genetic Analysis of the Drosophila 63F Early Puff: Characterization of
Mutations in E63-1 and maggie, a Putative Tom22
Martina Vaskova,* A. M. Bentley,* Samantha Marshall,
Pamela Reid,
Carl S. Thummel
and Andrew J. Andres*
*Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois 60611-3093
and
Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112-5331
Manuscript received March 20, 2000
Accepted for publication May 16, 2000
ABSTRACT
The 63F early puff in the larval salivary gland polytene chromosomes contains the divergently transcribed
E63-1 and E63-2 ecdysone-inducible genes. E63-1 encodes a member of the EF-hand family of Ca2
-binding
proteins, while E63-2 has no apparent open reading frame. To understand the functions of the E63 genes,
we have determined the temporal and spatial patterns of E63-1 protein expression, as well as undertaken
a genetic analysis of the 63F puff. We show that E63-1 is expressed in many embryonic and larval tissues,
but the third-instar larval salivary gland is the only tissue where increases in protein levels correlate with

  

Source: Andres, Andrew - School of Life Sciences, University of Nevada at Las Vegas

 

Collections: Biology and Medicine