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J. Phys. II France 6 (1996) 10231047 JULY 1996, PAGE 1023 Protein Adsorption on Lipid Monolayers

Summary: J. Phys. II France 6 (1996) 1023­1047 JULY 1996, PAGE 1023
Protein Adsorption on Lipid Monolayers
at their Coexistence Region
Roland R. Netz (1,,), David Andelman (1) and H. Orland (2,)
) School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences,
Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel
) Service de Physique Th´eorique, CE-Saclay, 91191 Gif sur Yvette Cedex, France
(Received 2 October 1995, accepted 26 March 1996)
PACS.82.70.-y ­ Disperse systems
PACS.87.22.Bt ­ Membrane and subcellular physics and structure
PACS.64.75.+g ­ Solubility, segregation, and mixing; phase separation
Abstract. -- We investigate theoretically the behavior of proteins as well as other large macro-
molecules which are incorporated into amphiphilic monolayers at the air-water interface. We
assume the monolayer to be in the coexistence region of the "main" transition, where domains of
the liquid condensed phase coexist with the liquid expanded background. Using a simple mean-
field free energy accounting for the interactions between proteins and amphiphilic molecules,
we obtain the spatial protein distribution with the following characteristics. When the proteins
preferentially interact with either the liquid condensed or liquid expanded domains, they will


Source: Andelman, David - School of Physics and Astronomy, Tel Aviv University


Collections: Materials Science; Physics