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Prefrontal cortical hyperactivity in patients with sympathetically mediated chronic pain
 

Summary: Prefrontal cortical hyperactivity in patients with sympathetically
mediated chronic pain
A. Vania Apkariana,*, P. Sebastian Thomasb
,
Beth R. Kraussc
, Nikolaus M. Szeverenyid
a
Department of Physiology, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, IL 60611, USA
b
Department of Anesthesia, SUNY Upstate Medical University, Syracuse, New York, NY 13210, USA
c
Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, New York, NY 13210, USA
d
Department of Radiology, SUNY Upstate Medical University, Syracuse, New York, NY 13210, USA
Received 27 April 2001; received in revised form 12 July 2001; accepted 12 July 2001
Abstract
Chronic pain continues to impose a large burden of suffering, yet its neural correlates remain poorly understood. In
sympathetically mediated chronic pain (SMP), peripheral sympathetic blockade temporarily relieves this pain, so that
related neural activity can be studied without perturbing sensory inputs. We used functional magnetic resonance
imaging and thermal painful stimuli applied to the chronically painful body site, before and after sympathetic blockade,

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine