Vol. 75, No. 2, February 1996. Printed in U.S.A.
Cellular Short-Term Memory From a Slow Potassium Conductance
GINA G. TURRIGIANO, EVE MARDER, AND L. F. ABBOTT
Department of Biology and Volen Center, Brandeis University, Waltham, Massachusetts02254
SUMMARY AND CONCLUSIONS
I. We use the dynamic clamp to add the slowly inactivating
and slowly recovering K' conductance Kv1.3 to cultured stomato-
gastric ganglion neurons.
2. Intro duction of Kvl.3 produced long delays to firing during
depolarization. Additionally, the slow recovery from inactivation
produced an increase in neuronal excitability after a depolarizing
input that outlasted the input by many seconds. Finally, when
introduced into bursting neurons, Kvl.3 produced a long-lasting
depolarization-induced switch between tonic and burst firing.
3. These data demonstrate that the slow kinetics of a K+ con-
ductance can produce a form of cellular short-term memory that
is independent of any changes in synaptic efficacy.