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Nature GeNetics VOLUME 42 | NUMBER 11 | NOVEMBER 2010 937 A rt i c l e s
 

Summary: Nature GeNetics VOLUME 42 | NUMBER 11 | NOVEMBER 2010 937
A rt i c l e s
Obesityisgloballyprevalentandhighlyheritable,butitsunderlyinggeneticfactorsremainlargelyelusive.Toidentifygeneticloci
forobesitysusceptibility,weexaminedassociationsbetweenbodymassindexand~2.8millionSNPsinupto123,865individuals
withtargetedfollowupof42SNPsinupto125,931additionalindividuals.Weconfirmed14knownobesitysusceptibilityloci
andidentified18newlociassociatedwithbodymassindex(P<510-8),oneofwhichincludesacopynumbervariantnear
GPRC5B.Someloci(atMC4R,POMC,SH2B1andBDNF)mapnearkeyhypothalamicregulatorsofenergybalance,andoneof
theselociisnearGIPR,anincretinreceptor.Furthermore,genesinothernewlyassociatedlocimayprovidenewinsightsinto
humanbodyweightregulation.
19 loci associated with BMI at P < 5 10-8 (Table 1, Fig. 1a and
Supplementary Table 1). These 19 loci included all ten loci from
previous GWAS of BMI610, two loci previously associated with body
weight10 (at FAIM2 and SEC16B) and one locus previously associated
with waist circumference14 (near TFAP2B). The remaining six loci,
near GPRC5B, MAP2K5-LBXCOR1, TNNI3K, LRRN6C, FLJ35779-
HMGCR and PRKD1, have not previously been associated with BMI
or other obesity-related traits.
Stage2followupidentifiesadditionalnewlociforBMI
To identify additional BMI-associated loci and to validate the loci
that reached genome-wide significance in the stage 1 analyses, we

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan
Nyholt, Dale R. - Genetic Epidemiology Laboratory, Queensland Institute of Medical Research

 

Collections: Biology and Medicine; Mathematics