Summary: Purification, structural characterization, and myotropic
activity of a peptide related to des-Arg9
-bradykinin from
an elasmobranch fish, the little skate, Leucoraja erinacea
W. Gary Anderson a,
*, Je´ro^me Leprince b
, J. Michael Conlon c
a
Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada R3T 2N2
b
European Institute for Peptide Research and INSERM U-413, CNRS, University of Rouen, 76821 Mont-Saint-Aignan, France
c
Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al-Ain,
United Arab Emirates
1. Introduction
The kallikrein­kinin system (KKS) in the plasma of mammals
involves activation of Hageman factor (factor XII) by contact
with a charged surface resulting in the activation of
prekallikrein and subsequent cleavage of high molecular
mass kininogen to generate bradykinin (BK) [2]. BK is the

Source: Anderson, W. Gary - Department of Biological Sciences, University of Manitoba

Collections: Biology and Medicine