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Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy
 

Summary: Brain activity for spontaneous pain of postherpetic neuralgia
and its modulation by lidocaine patch therapy
P.Y. Geha a
, M.N. Baliki a
, D.R. Chialvo a
, R.N. Harden b
,
J.A. Paice c
, A.V. Apkarian a,*
a
Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago, IL 60611, USA
b
Rehabilitation Institute of Chicago, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago, IL 60611, USA
c
Department of Medicine, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago, IL 60611, USA
Received 3 April 2006; received in revised form 4 August 2006; accepted 5 September 2006
Abstract
Postherpetic neuralgia (PHN) is a debilitating chronic pain condition, yet there is a lack of knowledge regarding underlying brain
activity. Here we identify brain regions involved in spontaneous pain of PHN (n = 11) and determine its modulation with Lidoderm
therapy (patches of 5% lidocaine applied to the PHN affected body part). Continuous ratings of fluctuations of spontaneous pain

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine