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Veterinary Parasitology 115 (2003) 125145 Control of tsetse flies and trypanosomes

Summary: Veterinary Parasitology 115 (2003) 125145
Control of tsetse flies and trypanosomes
using molecular genetics
Serap Aksoy
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
Tsetse flies (Diptera: Glossinidae) are important agricultural and medical vectors transmitting
the African trypanosomes, the agents of sleeping sickness disease in humans and various diseases
in animals (nagana). While the prevalence of disease has increased to epidemic proportions, lack
of a mammalian vaccine and affordable and effective drugs have hindered disease control. Try-
panosomiasis management relies heavily on the control of its single insect vector, the tsetse fly.
Despite the effectiveness of some of these tools, their impact on disease control has not been sus-
tainable due to their local nature and extensive dependence on community participation. Recent
advances in molecular technologies and their application to insects have revolutionized the field
of vector biology, and there is hope that such new approaches may form the basis for future tsetse
interventions. The success of the genetic approaches aiming to disrupt the transmission cycle of the
parasite in their invertebrate host depends on full understanding of the interaction between tsetse
and trypanosomes. This article reviews the biology of trypanosome development in the fly and the
multiple bacterial symbionts that inhabit the same gut environment. The availability of a genetic
transformation system for the midgut symbiont allows for gene products to be expressed in vivo


Source: Aksoy, Serap - School of Public Health, Yale University


Collections: Biology and Medicine